Apigenin 100mg x 90 Capsules - Third Party Tested Over 98% - Natural Apigenin Supplement Vitality Pro

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Apigenin can improve your cardiovascular health by reducing inflammation and blood pressure, which are two of the most significant risk factors regarding heart health. This benefit was shown in a study conducted on rats. This study has shown Apigenin to have cardioprotective effects in heart damaged rats. The researchers suggest that this is due to Apigenin's ability to suppress myocardial apoptosis (heart cell death) and inflammation by decreasing the activity of a major inflammatory pathway ( 15). What is the recommended Apigenin dosage?

While our focus here is on oral delivery of apigenin and its formulations, nanoparticles would also be advantageous if an intravenous route were being considered and would likely circumvent problems such as apigenin’s rapid crystallization into plasma post-delivery ( Karim et al., 2017). Injectable nanoparticle drug delivery systems include lipid nanocapsules, polymeric nanoscapsules, and liposomes ( Karim et al., 2017). These confer a number of benefits, including: i) good encapsulation of apigenin and loading capacity, ii) stability during storage, iii) reduced cytotoxicity, and iv) extended release of apigenin due to a less pronounced carrier burst effect ( Karim et al., 2017). Discussion Challenges and Opportunities in the Therapeutic Use of Apigenin Whether the administration of apigenin will indeed achieve clinically beneficial outcomes requires focused studies that combine direct measurements of plasma apigenin levels with clinical outcomes during chemotherapy. Although studies of oral and parenteral administration of apigenin in rat models have produced some valuable pharmacokinetic data ( Wan et al., 2007; Chen et al., 2011; Teng et al., 2012; Ding et al., 2014) there has been very little direct pharmacokinetic assessment in humans and it has been restricted to dosing with the dietary natural product such as parsley ( Meyer et al., 2006). Full assessment of apigenin and metabolites, and particular intra-patient variability given the variation in apigenin absorption and bioavailability noted above, need to be factored in alongside assessment of safety and toxicity in phase I clinical trials. Observational studies looking at consumption of apigenin within whole foods in the human diet indicate daily intake between 0.45 and 1.17mg–varying between age and demographic( Meyer et al., 2006; Somerset and Johannot, 2008). Meyer and colleagues studied the bioavailability of apiin (apigenin-7-O-apiosylglucoside) following a single bolus of parsley–a food source with an exceedingly high concentration of apigenin ( Meyer et al., 2006). Blood and urine samples from 11 German adults (ages 23–41) were taken following a meal consisting of 2g parsley/kg body weight–which was equivalent to ∼17mg of apigenin ( Meyer et al., 2006). Plasma concentrations of apigenin ranged from 28–337nmol/L at 6–10h after consumption, and fell below detection at 28h ( Meyer et al., 2006). A total of 0.039mg (±0.03) of apigenin was recovered over 24h from urine samples ( Meyer et al., 2006). These low plasma and urine concentrations are expected based on some of the pharmacokinetic parameters that will be discussed below - such as rapid metabolism, excretion of unabsorbed apigenin in non-urinary pathways, or hydrolysis by colonic microflora ( Meyer et al., 2006). Absorption of Apigenin in the Gastrointestinal Tract SelfDecode has an AI-powered app that allows you to see how Apigenin benefits your personal genetic predispositions. These are all based on clinical trials. The red sad faces indicate an increased likelihood to develop conditions that Apigenin may improve. Some flavonoids, including apigenin, are able to modulate intestinal smooth muscle peristalsis–potentially facilitating their absorption( Gharzouli and Holzer, 2004). In vitro studies in guinea pigs show that apigenin interferes with muscle excitation and/or excitation-contraction, to decrease distension sensitivity and peristaltic performance in a concentration-dependent manner, thereby advantaging the absorption process ( Gharzouli and Holzer, 2004). Biliary excretion and recycling enables a significantly increased half-life of the compound and prolonged exposure of the intestinal mucosa ( Chen et al., 2003; Min et al., 2017). In addition to enterohepatic recycling, apigenin can also undergo local enteric recycling, in a concentration and metabolite-dependent manner ( Hu et al., 2003). These enterohepatic/enteric recycling processes will tend to favor the persistence of apigenin in the gastrointestinal tract but reduce net systemic absorption. Variability in Apigenin Absorption, and BioavailabilityFlavonoids as a sub-class are poorly bioavailable from the diet due to their low water solubility, chemical instability, and rapid metabolism in the body ( Leonarduzzi et al., 2009). Apigenin itself is however lipophilic and a weak acid, and therefore will be most permeable to cell membranes in the unionized form within acidic environments, allowing it to be better absorbed in lower pH environments along the gastrointestinal tract, including the stomach ( Leonarduzzi et al., 2009). In the pH range of the intestinal tract, hydrophobic apigenin is still able to permeate lipid membranes–enabling absorption along the full length of the intestines, but does so most effectively in the duodenum ( Tang et al., 2017). Cancer is a disease where cells grow uncontrollably and spread to other parts of the body. Chemotherapy is promoted as the best way to manage and kill cancer cells, despite its undesirable side effects. Therefore, scientists are testing and trialling compounds, like Apigenin, to treat various forms of this condition. A small trial testing an apigenin-containing beverage and 2 studies in mice cannot be considered sufficient evidence to claim that apigenin helps with weight loss. Larger, more robust clinical research testing this compound alone is needed. 4) Inflammation and Pain Testosterone is respected as one of the most important hormones in the human body, especially in regard to muscle growth, fat loss, energy levels and libido. Unfortunately, as we age and due to lifestyle factors, our production of this male sex hormone begins to decline. Before the discussion of the effects of dietary apigenin on gut bacteria, it is necessary to look at the dietary intake level of apigenin. The distribution of apigenin in the plant kingdom is wide, as it has been found in many vegetables, herbs, and fruits [ 5]. Fresh parsley, vine spinach, celery seed, green celery heart, Chinese celery, and dried oregano are dietary sources with high apigenin content [ 5]. Other plants in which apigenin has been identified include red and white sorghum, rutabagas, oranges, kumquats, onions, wheat sprouts, tea, and cilantro [ 5, 9, 18]. Dried parsley has a particularly high level of apigenin that far exceeds any other vegetables or herbs [ 5]. Chamomile tea, high in apigenin content, is one of the most common sources of apigenin intake from a single ingredient [ 19]. In nature, apigenin is typically found in a glycosylated form, with the tricyclic core structure linked to a sugar moiety through hydroxyl groups ( O-glycosides) or directly to carbon ( C-glycosides). The common apigenin glycosides are apiin, apigenin-7- O-glucoside, apigenin-8- C-glucoside (vitexin), apigenin-6- C-glucoside (isovitexin), apigenin-7- O-neohesperidoside (rhoifolin), and apigenin-6- C-glucoside 8- C-arabinoside (schaftoside) [ 4, 13, 20].

In a clinical trial on 87 people who underwent the surgical removal of colon tumors or polyps, a flavonoid mixture with 20 mg apigenin and 20 mg epigallocatechin gallate was associated with a lower development of colorectal tumors [ 21]. Apigenin is a naturally occurring flavonoid, most notably found in chamomile and many vegetables, fruits, and medicinal plants. It is known for its numerous health benefits, including anti-inflammatory, antioxidant, and anticancer properties. All the current research suggests that Apigenin is safe, even at doses exceeding what you would usually require through diet alone. However, if you experience any sort of digestive issues or irritations following ingesting, you should stop using the product. Speak to a healthcare professional before using Apigenin to treat a condition. Can women take Apigenin?Due to its anti-inflammatory properties, Apigenin can reduce discomfort and pain caused by inflammatory issues, such as delayed onset muscle soreness, digestive issues and migraines. Research has shown this compound to reduce the release of cytokines, and it is these molecules that are associated with feelings of pain ( 11). Fights Against Cancer We have a 30-day return policy, which means you have 30 days after receiving your item to request a return. As discussed in the previous section, Apigenin may increase testosterone and reduce cortisol levels, which creates an anabolic (muscle growth-promoting) environment in the body.

apigenin AND (HT-29 OR HT29 OR HCT-116 OR HCT116 OR HRT-18 OR HRT18 OR Caco-2 OR Caco2 OR T84 OR SW480 OR SW620 OR Colo-320 OR Colo320) Taken together, the evidence is insufficient to conclude that apigenin helps in cancer prevention. The human studies had mainly negative results, and those showing anticancer activity were mostly done in cells. In a clinical trial on 72 people suffering from migraine without aura, a chamomile oil gel with 0.233 mg/g apigenin reduced pain and other migraine symptoms (nausea, and discomfort caused by light and sounds) [ 11]. We are now able to achieve high intakes of this health-boosting antioxidant via supplementation. This enables you to attain the benefits of this flavonoid without stressing about dietary intake via food sources.There is incredibly promising research emerging about Apigenin's neuroprotective qualities. The most significant study suggests that Apigenin may be able to delay the onset of Alzheimer’s disease and decrease its rate of progression. Based on the results from a broad array of studies, they concluded that Apigenin is an exceptional candidate for anti-inflammatory therapy against Alzheimer’s disease, and can even improve memory in mice with Alzheimer’s disease ( 10). Pain Relief Dried parsley has been reported to have the highest apigenin content out of all foods, at 45 mg/g, whereas Celery's apigenin content is much lower at 0.7mg/g from seeds and 0.2 mg/g from Chinese Celery. Additionally, Chamomile is often regarded as a powerful apigenin dense flower, especially when drank in tea form, containing 3 to 5 mg/g. Apigenin Benefits Apigenin (4′, 5, 7-trihydroxyflavone) is a plant flavone that has been found to have various actions against cancer cells. We evaluated available evidence to determine whether it is feasible for apigenin to have such effects in human patients. While IV administration of apigenin would be disfavoured in humans as not being overtly justified, it would be predicted to enable biologically active concentrations. Indeed, IV delivery of apigenin (20mg/kg) in rats yielded a C max of 11.0 ± 1.7μg/ml ( Wan et al., 2007), which represents a plasma concentration in excess of 40μmol/L, sufficient to produce a response in all of the cell systems studied ( Table 4). Options to Enhance the Bioavailability of Apigenin Taken Orally A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota.