Akkermansia Muciniphila Probiotic Granules * Live Long * Weight Control Dogadan Bizim (5)

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Weichselbaum, L. & Klein, O. D. The intestinal epithelial response to damage. Sci. China Life Sci. 61, 1205–1211 (2018). Yan, J.; Sheng, L.; Li, H. Akkermansia muciniphila: Is it the Holy Grail for ameliorating metabolic diseases? Gut Microbes 2021, 13, 1984104. [ Google Scholar] [ CrossRef] [ PubMed] Zhang T, Li Q, Cheng L, Buch H, Zhang F. Akkermansia muciniphila is a promising probiotic. Microb Biotechnol. 2019 Nov;12(6):1109-1125.

Jang, Y. J., Kim, W.-K., Han, D. H., Lee, K. & Ko, G. Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota. Gut microbes 10, 696–711 (2019). Callahan, B. J. et al. DADA2: high-resolution sample inference from Illumina amplicon data. Nat. Methods 13, 581–583 (2016). De Nies, L.; Busi, S.B.; Tsenkova, M.; Halder, R.; Letellier, E.; Wilmes, P. Evolution of the murine gut resistome following broad-spectrum antibiotic treatment. Nat. Commun. 2022, 13, 2296. [ Google Scholar] [ CrossRef] College of Veterinary Medicine, Sichuan Province Key Laboratory of Animal Disease and Human Health, Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, China Zhang, L. et al. Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health. J. nutritional Biochem. 56, 142–151 (2018).The ‘muciniphila’ part comes from Akkermansia’s love of mucus. That’s right, it loves to eat the slimy layer of mucus that coats our intestinal walls. It keeps us healthy at the same time, so that’s a good thing. Zhang, T.; Ji, X.; Lu, G.; Zhang, F. The potential of Akkermansia muciniphila in inflammatory bowel disease. Appl. Microbiol. Biotechnol. 2021, 105, 5785–5794. [ Google Scholar] [ CrossRef] Perraudeau F, McMurdie P, Bullard J, et al. Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double-blind, randomized placebo-controlled trial of a novel probiotic formulation. BMJ Open Diabetes Res Care. 2020 Jul;8(1):e001319.

Dao, M. C. et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut 65, 426–436 (2016). However, if your diet isn’t as good as it could be, or you’re looking for a boost, high-quality supplements from natural sources can really help. For instance, research has shown that fish oil does boost Akkermansia levels Source: NCBI. Varesi, A.; Campagnoli, L.I.M.; Fahmideh, F.; Pierella, E.; Romeo, M.; Ricevuti, G.; Nicoletta, M.; Chirumbolo, S.; Pascale, A. The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment. Int. J. Mol. Sci. 2022, 23, 12289. [ Google Scholar] [ CrossRef] Bárcena, C. et al. Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice. Nat. Med. 25, 1234–1242 (2019).Chen, M. et al. Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system. Clin. Nutr. (Edinb., Scotl.) 39, 1264–1275 (2020). Craft, J. E. Follicular helper T cells in immunity and systemic autoimmunity. Nat. Rev. Rheumatol. 8, 337–347, https://doi.org/10.1038/nrrheum.2012.58 (2012). The mucus layer is very important for gut health and for the health of your whole body. This could be a big reason why Akkermansia has been found to be so beneficial. While it chows down, Akkermansia produces nutrients that feed our other good gut bacteria. Nadeem, M.S.; Kumar, V.; Al-Abbasi, F.A.; Kamal, M.A.; Anwar, F. Risk of colorectal cancer in inflammatory bowel diseases. Semin. Cancer Biol. 2020, 64, 51–60. [ Google Scholar] [ CrossRef]

Bornet, E. & Westermann, A. J. The ambivalent role of Bacteroides in enteric infections. Trends Microbiol. 30, 104–108 (2022). Shen, J.; Tong, X.; Sud, N.; Khound, R.; Song, Y.; Maldonado-Gomez, M.X.; Walter, J.; Su, Q. Low-Density Lipoprotein Receptor Signaling Mediates the Triglyceride-Lowering Action of Akkermansia muciniphila in Genetic-Induced Hyperlipidemia. Arter. Thromb. Vasc. Biol. 2016, 36, 1448–1456. [ Google Scholar] [ CrossRef] However, the higher abundance of A. muciniphila may not be negatively correlated with IBD. A surprising result shows in both CRC patients and CRC mice, the abundance of A. muciniphila is higher than that in healthy people 57, 58 (Supplementary Table 1). Moreover, A. muciniphila is enriched in the early stage of CRC 59. The abundance of A. muciniphila may also be increased by pathogenic infection 60, 61 (Supplementary Table 1). Diet and lifestyle can regulate the abundance of A. muciniphila Zhang, X. et al. Age-related compositional changes and correlations of gut microbiome, serum metabolome, and immune factor in rats. GeroScience 43, 709–725 (2021). Because we only discovered Akkermansia 15 years ago, research has really only just begun. If you need help to understand how boosting your levels of Akkermansia could help your health condition, and how best to do it, you can talk to a Functional Medicine Practitioner or Registered Nutritional Therapist.

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Lim, J. S., Lee, D. H., Park, J. Y., Jin, S. H. & Jacobs, D. R. Jr. A strong interaction between serum γ-glutamyltransferase and obesity on the risk of prevalent type 2 diabetes: results from the Third National Health and Nutrition Examination Survey. Clin. Chem. 53, 1092–1098 (2007). Wang, Q., Garrity, G. M., Tiedje, J. M. & Cole, J. R. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl. Environ. Microbiol. 73, 5261–5267 (2007). Scherbaum, W. A. et al. Efficacy and tolerability of vildagliptin in drug-naïve patients with type 2 diabetes and mild hyperglycaemia. Diabetes Obes. Metab. 10, 675–682 (2008).