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In severe cases of malabsorption or in people with risk factors for vitamin B12 deficiencies, a liquid supplement could help prevent deficiency and associated symptoms. It may even have a few additional health benefits. Used to treat anemia Includes a variety of vegetables; fruits; grains (at least half whole grains); fat-free and low-fat milk, yogurt, and cheese; and oils. The other three are chemically identical to the vitamin B12 that’s found in foods. Still, when used in supplements, they’re produced in a lab rather than being isolated from natural sources. SUMMARY These cases were due to allergies to cobalt molecules or other ingredients in the supplements, like benzyl alcohol. An allergic reaction could cause symptoms, including ( 26, 27):
Use a humidifier. Dry, warm air can worsen your symptoms. Use a humidifier to increase moisture in the room. Walsh, Karla. "8 Best Vitamin B12 Supplements to Help Boost a Low Intake, According to Experts." Prevention, 14 Mar. 2022, www.prevention.com/food-nutrition/g35351378/best-b12-supplements/.
Do I Need a Supplement?
There are several forms of vitamin B12, including cyanocobalamin, which is the most common, as well as adenosylcobalamin, methylcobalamin, and hydroxycobalamin. Most observational studies have found correlations between low serum vitamin B12 concentrations alone or in combination with high folate concentrations and poor cognitive function [ 82-87]. For example, an analysis of cross-sectional 2011–2014 NHANES data on 2,420 adults age 60 years or older found that low vitamin B12 (MMA greater than 0.27 micromol/L or serum vitamin B12 less than 203 pg/mL [150 pmol/L]) combined with high folic acid—unmetabolized serum folic acid greater than 0.44 mcg/L (1 nmol/L) or serum total folate higher than 32.7 mcg/L (74.1 nmol/L)—was associated with an almost two to three times higher risk of cognitive impairment [ 82].
Still, vitamin B12 deficiencies are fairly common, particularly among older adults, people who follow a vegan diet, and those who take certain medications. Hwang JS, et al. (2019). Vitamin D enhances the efficacy of topical artificial tears in patients with dry eye disease. One downside to this product is that it contains sorbitol, a sugar alcohol, though it will likely not cause GI side effects in the low dose included in this supplement.Anemia makes you feel weak and fatigued. Severe cases can even damage the heart and nervous systems. Estimated Average Requirement (EAR): Average daily level of intake estimated to meet the requirements of 50% of healthy individuals; usually used to assess the nutrient intakes of groups of people and to plan nutritionally adequate diets for them; can also be used to assess the nutrient intakes of individuals Sharabi A, Cohen E, Sulkes J, Garty M. Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route. Br J Clin Pharmacol. 2003;56(6):635-638. doi:10.1046/j.1365-2125.2003.01907.x Bhargava R, et al. (2016). A randomized controlled trial of omega 3 fatty acids in rosacea patients with dry eye symptoms. Both vitamin B12 deficiency and folate deficiency are more common in older people, affecting around 1 in 10 people aged 75 or over and 1 in 20 people aged 65 to 74. Treating vitamin B12 or folate deficiency anaemia
When looking for a B12 supplement, consider whether you want a supplement with only B12 or a multivitamin that includes other nutrients important for vegans and vegetarians such as vitamin D, omega-3 fats, iron, calcium, iodine, zinc, and selenium. You will also want to consider a dose appropriate for your needs and whether you prefer supplements in pill, spray, or sublingual (under the tongue) form. The estimated bioavailability of vitamin B12 from food varies by vitamin B12 dose because absorption decreases drastically when the capacity of intrinsic factor is exceeded (at 1–2 mcg of vitamin B12) [ 16]. Bioavailability also varies by type of food source. For example, the bioavailability of vitamin B12 appears to be about three times higher in dairy products than in meat, fish, and poultry, and the bioavailability of vitamin B12 from dietary supplements is about 50% higher than that from food sources [ 17-19]. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Damayanti D, Jaceldo-Siegl K, Beeson WL, Fraser G, Oda K, Haddad EH. Foods and supplements associated with vitamin B(12) biomarkers among vegetarian and non-vegetarian participants of the Adventist Health Study-2 (AHS-2) Calibration study. Nutrients 2018;10:722. [ PubMed abstract]
Complications of vitamin B12 or folate deficiency anaemia
Not all third-party testing is created equal. It is not uncommon for supplement companies to pay labs for certificates after conducting minimal to no testing. In addition to taking dry eye supplements, you can also try other home remedies to alleviate your symptoms. Thorne’s B-complex capsules will provide you with 100 mcg of vitamin B12 as methylcobalamin. They also contain vitamin B1, B2, B3, B5, B6, B7, B9, and choline.
Slot WB, Merkus FW, Van Deventer SJ, Tytgat GN. Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology 1997;113:430-3. [ PubMed abstract] Vitamin b12: Fact Sheet for Health Professionals. National Institutes of Health Office of Dietary Supplements. Adequate Intake (AI): Intake at this level is assumed to ensure nutritional adequacy; established when evidence is insufficient to develop an RDAMany gummies are made with gelatin, which isn’t suitable for vegans and vegetarians. Mary Ruth’s is an entirely vegan supplement brand—each supplement is vegan, gluten free, and non-GMO. Their products are also third party tested for potential contaminants. Vitamin B12 supplements should be easy to use. If you have trouble swallowing pills and capsules, the best vitamin B12 liquid drops can help. These types of liquid vitamins can be taken in liquid dropper form, a sublingual dosage, or even a spray. Make sure to pay attention to dosing when you incorporate a vitamin B12 supplement into your diet, as the daily recommended dietary allowance of vitamin B12 for adults is 2.4 micrograms. You should only waver from that dosing if your doctor recommends that you do so. The Best Vitamin B12 Liquid Supplements
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