Best Naturals Inositol 1000 mg 60 Tablets

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Clinical studies suggest inositol supplements may be beneficial for those with metabolic syndrome ( 21, 22). It has been revealed that, dietary MI supplementation in vivo is beneficially associated with lipid metabolism, bone formation, skeletal muscle metabolism, reproduction, nerve function, and brain actions. It must be noticed that inositol is categorized as generally recognized as safe (GRAS) supplement by the FDA. HPS2-THRIVE Collaborative Group. Effects of extended-release niacin with laropiprant in high-risk patients. New Engl J Med 2014;371:203-12. [ PubMed abstract] Giordano D, Corrado F, Santamaria A, et al. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: A perspective, randomized, placebo-controlled study. Menopause. 2011;18(1):102-104. doi:10.1097/gme.0b013e3181e8e1b1

According to self-reported data from the 2013–2014 NHANES, 21% of all individuals age 2 and older took a dietary supplement containing niacin [ 16]. The proportion of users increased with age from 8% of those age 12–19 years to 39% of men and 40% of women age 60 and older. Supplement use doubled or tripled total niacin intakes compared with intakes from diet alone. According to data from the 2003–2006 NHANES, 10% of all individuals age 2 and older who took dietary supplements had total niacin intakes that reached or exceeded the UL [ 19]. Niacin Deficiency Cheng SC, Young DO, Huang Y, Delmez JA, Coyne DW. A randomized, double-blind, placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients. Xlin J Am Soc Nephrol 2008;3:1131-8. [ PubMed abstract] A.S., et al., Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach. Trends Endocrinol Metab, 2018. 29(11): p. 768-780.Nicotinic acid in supplemental amounts beyond nutritional needs can cause skin flushing, so some formulations are manufactured and labeled as prolonged, sustained, extended, or timed release to minimize this unpleasant side effect. Nicotinamide does not produce skin flushing because of its slightly different chemical structure [ 2, 12]. Niacin supplements are also available in the form of inositol hexanicotinate, and these supplements are frequently labeled as being flush free because they do not cause flushing. The absorption of niacin from inositol hexanicotinate varies widely but on average is 30% lower than from nicotinic acid or nicotinamide, which are almost completely absorbed [ 12-14]. Two niacin-like compounds, nicotinamide riboside and nicotinamide mononucleotide (NMN; also referred to as β-NMN), are also available as dietary supplements, but are not marketed or labeled as sources of niacin [ 11]. However, FDA ruled in November 2022 that NMN may not be legally marketed as a dietary supplement because it has been authorized for investigation by FDA as a new drug [ 15]. Medications

E.J., et al., Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA). Br J Nutr, 2018. 120(1): p. 111-120. Amazingly, 20% of the women taking inositol supplements no longer met the criteria for metabolic syndrome by the end of the study ( 24). Summary Over time, inositol therapy results in better hormone balance for all types of PCOS [ 5, 6, 14]. 3. Myo-Inositol Can Enhance Fertility Table 1 lists the current RDAs for niacin as mg of niacin equivalents (NE) [ 2]. The FNB defines 1 NE as 1 mg niacin or 60 mg of the amino acid tryptophan (which the body can convert to niacin). Niacin RDAs for adults are based on niacin metabolite excretion data. For children and adolescents, niacin RDAs are extrapolated from adult values on the basis of body weight. The AI for infants from birth to 6 months is for niacin alone, as young infants use almost all the protein they consume for growth and development; it is equivalent to the mean intake of niacin in healthy, breastfed infants. For infants age 7–12 months, the AI for niacin is in mg NE and is based on amounts consumed from breast milk and solid foods. Table 1: Recommended Dietary Allowances (RDAs) for Niacin [ 2] Age Crawford TJ, Crowther CA, Alsweiler J, Brown J. Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Cochrane Database Syst Rev. 2015;2015(12):CD011507. doi: 10.1002/14651858.CD011507.pub2Ovasitol by Theralogix is the market-leading inositol supplement for women with PCOS. And for good reason. Ovasitol contains myo-inositol and D-chiro-inositol in a 40:1 ratio. As described above, this is the most effective formulation for the treatment of PCOS.

Tryptophan is another food source of niacin because this amino acid—when present in amounts beyond that required for protein synthesis—can be converted to NAD, mainly in the liver [ 3, 5]. The most commonly used estimate of efficiency for tryptophan conversion to NAD is 1:60 (i.e., 1 mg niacin [NAD] from 60 mg tryptophan). Turkey is an example of a food high in tryptophan; a 3-oz portion of turkey breast meat provides about 180 mg tryptophan, which could be equivalent to 3 mg niacin [ 9]. However, the efficiency of the conversion of tryptophan to NAD varies considerably in different people [ 3]. Chiappelli J, Rowland LM, Wijtenburg SA, et al. Evaluation of myo-inositol as a potential biomarker for depression in schizophrenia. Neuropsychopharmacol. 2015;40(9):2157-2164. doi:10.1038/npp.2015.57 Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Also, inositol acted as an osmolyte in some tissues, such as kidney medulla and brain, where osmolarity has a pivotal biological meaning. In their guidelines for lowering blood cholesterol levels, the American College of Cardiology and the American Heart Association advise that nonstatin therapies, compared with or in addition to statin therapy, do not provide atherosclerotic cardiovascular disease risk-reduction benefits that outweigh the potential harms of their adverse effects [ 29]. When discussing the use of nicotinic acid supplements to reduce the risk of hyperlipidemia (for example, in patients unable to tolerate statin medications), the two professional societies recommend that patients take 500 mg/day extended-release nicotinic acid supplements and increase the dose to a maximum of 2,000 mg/day over 4 to 8 weeks or take 100 mg immediate-release nicotinic acid three times a day and increase the dose to 3,000 mg/day divided into two or three doses. (Their joint statement about monitoring supplement users who take niacin to reduce hyperlipidemia risk for adverse effects is described in the Health Risks from Excessive Niacin section below.) In their 2018 report, these two professional societies stated what although niacin may be useful in some cases of severe hypertriglyceridemia, it has only mild LDL-lowering effects. The societies therefore do not recommend using it as an add-on drug to statin therapy [ 35].For blood sugar control in gestational diabetes: 2 grams of MYO and 400 mcg of folic acid twice daily during pregnancy ( 29, 30, 31). While there is an endogenous production from glucose‐6‐phosphate, the major part of inositol comes from the exogenous sources like citrus fruits, beans, artichokes and most of other plants. Duan J, Zhang M, Zhang H, Xiong H, Liu P, Ali J, Li J, Li Z (2012) OsMIOX, a myo-inositol oxygenase gene, improves drought tolerance through scavenging of reactive oxygen species in rice ( Oryza sativa L.). Plant Sci 196:143–151