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As a sufferer of cold sores all year round this little tube is a life saver. Due to design of the tube (looks like a lip gloss once opened) it can be applied directly to the affected area. I made sure I gave it a good wipe after application though as I wouldn’t want to risk spreading to other areas of my mouth. Subjects were excluded if they showed limited compliance, suffered from severe illnesses, or had taken antibiotics or anti-inflammatory drugs two weeks ahead of participation. Pregnant or breastfeeding females were excluded. Hypersensitivity against the ingredients contained in the products or alcohol or drug abuse were additional exclusion criteria. If the patient had already applied a product for the treatment of HSL on the present lesion or had participated in a different clinical study, the subject was not allowed to participate. One huge bonus for me was when going outside I hardly felt the cold against my lip. No nip or tingle at all and more importantly no scarf needed to protect my mouth. So in other words I loved it! I’ve used other kinds of patches and creams in the past and whilst some have helped this is by far the best protective barrier which makes the cold sore much less noticeable. I try to catch my cold sores at the tingly stage and it doesn’t always work but using this serum I felt confident after 2 days it was gone with little progression into a full blown blistering mess. Not that I’m looking forward to my next cold sore but it will be interesting to see if these great results continue. I’d definitely recommend this product to anyone who suffers from cold sores and with a good price for most budgets a good investment. Gross, G. & Braun, D. Efficacy and tolerability of topical foscarnet sodium in treatment of herpes labialis: Results of post-marketing surveillance. Hautarzt 57, 40–46 (2006).
Malvy, D. et al. Epidemiology of orofacial herpes simplex virus infections in the general population in France: results of the HERPIMAX study. J. Eur. Acad. Dermatol. 21, 1398–1403 (2007). The course of disease in recurrent HSL generally involves several stages. Within the precursor stage, pain, tingling, or burning sensations in the affected area may occur. This is followed by the appearance of a macule, turning into a papule and leading to the formation of a vesicle. The vesicle bursts, and the formation of a soft scab is initiated. Subsequently, the soft scab is replaced by a hard scab. Over time, the scab falls off, and the lesion is fully healed without scarring 6, 7, 8. While healing, the process is often accompanied by symptoms such as pain, discomfort or reduced self-esteem 6. Complete healing takes seven to ten days 7. An alternative is provided in the Compeed Invisible Cold Sore Patches that include no antiviral ingredient (Compeed; Johnson & Johnson Santé Beauté France SAS, Sézanne, France). The cytotoxicity was tested on fibroblasts. Further studies examined the irritation of the patches on rabbits and the sensitivity on guinea pigs. The outer layer of the patch consists of a semiocclusive polyurethane film, which allows excessive wound exudate to evaporate while keeping the lesion moist, ensuring an optimum moisture level. The patch seals the wound and arranges ideal conditions for wound healing. The patch functions as a shield, protecting surrounding areas from infection. As soon as the first symptoms occur, the patch is placed on the lesion, replaced if required, and worn for 24 hours until complete healing occurs 19.Arduino, P. G. & Porter, S. R. Oral and perioral herpes simplex virus type 1 (HSV-1) infection: review of its management. Oral Dis. 12, 254–270 (2006). Zahvaljujući svojoj super hranjivoj formuli s prirodnim voskovima i aloe verom, Herpatch balzam za sprječavanje herpesa smiruje, hidratizira i obnavlja osjetljive i ispucale usne, ali i daje dugotrajno olakšanje.
The Kolmogorov-Smirnov, Kruskal-Wallis, and Mann-Whitney U tests were used to determine the existence of statistically significant differences among the three tested products regarding the secondary endpoint. After Bonferroni correction, the probability of error p and the level of significance were defined as p = 0.025. Ne nazadnje pa cinkov sulfat zmanjša bolečino in srbečico, njegovo delovanje je tudi adstringentno, tako da kožo utrdi, okrepi in poveča njeno prožnost. Cinkov sulfat s tem pospeši celjenje kože na predelih s herpesom. Darai, G., Handermann, M., Sonntag, H. G., Tidona, C. & Zöller, L. In Lexikon der Infektionskrankheiten des Menschen (Third Edition) (ed. Gholamreza Darai) 388–91 (Springer, 2009).
O serumu
Korr, G. et al. Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control. BMC Infect. Dis. 17, 471 (2017). Spruance, S. L. et al. Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir. Antimicrob. Agents Chemother. 25, 553–555 (1984).
U.S. Food and Drug Administration. ZOVIRAX (acyclovir) cream 5% for topical use - Reference ID: 3481551 (2014). To produce significant results, the sample size was estimated with the programme G*Power 3.1.9.2 23. A sample size of 180 patients (60 participants per treatment group) was calculated with a statistical power of 0.8, an alpha error of 0.05, and a 15% drop-out quote with an effect size of 0.5. All data were statistically analysed with the program SPSS 24.0. Petti, S. & Lodi, G. The controversial natural history of oral herpes simplex virus type 1 infection. Oral Dis. 25, 1850–1865 (2019).
Sulfatni polisaharidi, koji potječu iz crvenih mikroalgi, stvaraju aktivan zaštitni sloj i na taj način pomažu u zaštiti od izlaganja sunčevoj svjetlosti; Semprini, A. et al. Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: a randomised controlled trial. BMJ Open 9 (2019). Shaw, M. et al. Failure of acyclovir cream in treatment of recurrent herpes labialis. BMJ Open 291, 7–9 (1985). I’ve already tried several products for the treatment of cold sores, and only Herpatch charm me. It works very effectively and is, moreover, easy to apply and transparent.
Aktivni kisik pospeši obnovo celic, poveča vlažnost kože in s tem skrajša čas celjenja kože s herpesom. Al-Waili, N. S. Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions. Med. Sci. Monit. 10, 94–98 (2004). The statistical analysis of the reaction rate and the reaction quality showed statistically significant differences between Herpatch and Compeed as well as between Herpatch and Zovirax, both in favour of Herpatch. Karlsmark et al. evaluated the same parameters without assessing statistically significant differences between Compeed and Zovirax 22. Hydrocolloid wound dressings such as the Compeed patches promote re-epithelialization and reduce inflammatory responses 41, 42. However, in this clinical trial, the patch had to be removed several times due to the patch margins peeling off. This was caused particularly by liquids such as saliva, food or drinks or by facial expressions. The peeled-off margins led to discomfort and caused the patient to renew the patch. With every replacement, already formed crusts were torn off with the patch, causing pain while promoting primary wound healing. Accompanying symptoms such as pain, tingling, swelling, or burning were also assessed in comparable trials 43, 44. The duration and intensity of symptoms were rated and showed comparable distributions independent of the applied product. This evaluation is important to prove the effective impact of treatment on healing. Gently apply a small amount of serum that will form a film on the cold wound, adequately covering the lesions and a margin of healthy skin around them. After a few minutes, the white serum forms a transparent protective film on the cold wound. If necessary, the serum can be reapplied every 3-4 hours until the cold wound is completely healed. The film can be removed, if necessary, with hot water. Finally, zinc sulphate reduces pain and itching and has an astringent action, which firms, tones and strengthens the skin. Zinc sulfate will therefore also help to accelerate healing of cold sore lesions.Sulfated polysaccharides, which are derived from red microalgae, will create an active protective barrier and as such, will help to protect against sunlight exposure; Khemis, A. et al. Evaluation of the efficacy and safety of a CS20 (R) protective barrier gel containing OGT compared with topical aciclovir and placebo on functional and objective symptoms of labial herpes recurrences: a randomized clinical trial. J. Eur. Acad. Dermatol. 26, 1240–1246 (2012). Chen, F. et al. Efficacy and safety of nucleoside antiviral drugs for treatment of recurrent herpes labialis: a systematic review and meta-analysis. J. Oral Pathol. Med. 46, 561–568 (2017). Pica, F. & Volpi, A. Public awareness and knowledge of herpes labialis. J. Med. Virol. 84, 132–137 (2012).
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