BiOptimizers Magnesium Breakthrough Supplement 4.0 - Has 7 Forms of Magnesium: Glycinate, Malate, Citrate, and More - Natural Sleep and Brain Supplement - 60 Capsules

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To boost mood and promote a healthy stress response, it is best to use a combination of forms of magnesium combined with vitamin B6. Studies have confirmed that magnesium with organic acid salt (e.g. citrate and malate) or amino acids (e.g. taurate, glycinate, and sucrosomial) are significantly better absorbed than inorganic salts (oxide, chloride, and sulfate). Also, these different forms are absorbed into different tissues, with taurate, malate, and citrate being the most beneficial for the nervous system Orchard TS, Larson JC, Alghothani N, et al. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study. Am J Clin Nutr. 2014;99(4):926-933. doi:10.3945/ajcn.113.067488 Bioptimizers Magnesium malate : Most individuals can get magnesium malate from their diet. Magnesium ions are common in most tart fruits. Research shows magnesium malate may alleviate stress, chronic pain, and migraines. DiNicolantonio JJ, Liu J, O'Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1. doi:10.1136/openhrt-2018-000775 Asemi Z, Karamali M, Jamilian M, et al. Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(1):222-229. doi:10.3945/ajcn.114.098616

Promotes Healthy Blood Pressure. A meta-analysis of 34 randomized control trials found that magnesium reduced blood pressure.[20] However, the effect size is clinically small (<2 mmHg). Therefore, it may be good for supporting overall health and healthy blood pressure, but you may also need other interventions to achieve healthy blood pressure levels. If we were getting adequate high-quality nutrition, we wouldn’t need a single supplement,” says Dr. Anderson. “But in this modern-day world, that just typically does not happen, and magnesium is a great example.” While BiOptimizers’ Magnesium Breakthrough claims to offer “all seven major forms” of magnesium, it’s important to note that there are additional forms not included in its proprietary blend. Notably, magnesium L-threonate, which is recognized for its unique ability to effectively cross the “blood-brain barrier” and potentially enhance cognitive function. Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B. Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women. J Res Med Sci. 2012;17(7):607-614

The Right Magnesium Supplement Can Give You **ALL SEVEN**

de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014

Magnesium is required by the human body to support nerve and muscle function. If you have enough magnesium ions in your body, you will have enough energy to last the entire day.It is better to take mineral supplements, such as magnesium, on an empty stomach because you will absorb it more efficiently. However, some people experience upset stomach, so they take it with food. Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B. Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women. J Res Med Sci. 2012;17(7):607-614. Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A. Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol. 2004;27(4):223-227. doi:10.1002/clc.4960270411 Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047

Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res. 2001;14(4):257-262. A magnesium supplement significantly improved mood after 2 weeks. Another trial found that magnesium supplements improved mood in seniors. Both Vitamin D and magnesium have important roles in bone health, immune function, and metabolism. Magnesium is a cofactor in vitamin D conversion and activation. Some people cannot increase their blood 25-hydroxy vitamin D levels despite supplementing with vitamin D3 because they are deficient in magnesium. In other words, magnesium deficiency can make vitamin D less effective. Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333. doi:10.1161/HYPERTENSIONAHA.116.07664Supports exercise performance and recovery. Magnesium supplementation improves speed and strength,[15] possibly by making glucose metabolism more efficient. It also supports the necessary stress response to exercise, reduces muscle damage,[16] and improves exercise recovery (400 mg/day, taken at breakfast). Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017;12(6):e0180067. Published 2017 Jun 27. doi:10.1371/journal.pone.0180067 For example, if you want help with bowel regularity, magnesium oxide or citrate can be used. However, if you already have loose stools, it’s best to avoid those types and opt for magnesium glycinate or malate, which support muscle and heart function. The absorption of magnesium depends on its binding to specific compounds, which determines its effects and usability within the body.