Synbiotic 7 Probiotic | Friendly Bacteria | High Strength | 40 Billion CFU Spanning 7 Scientifically Studied strains | Including Bacillus Subtilis | Vegan | Link Nutrition | No Refrigeration Needed

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Malik JK, Prakash A, Srivastava AK, Gupta RC (2019) Synbiotics in animal health and production. In: Gupta RC, Srivastava A, Lall R (eds) Nutraceuticals in veterinary medicine. Springer, Cham, pp 287–301 Everyone who tried this said their skin felt less dry and flaky after use. Testers mentioned their skin’s “plumped and hydrated” appearance and waxed lyrical about the “cool, refreshing sensation” when you apply the gel. Rabiei S, HedayatiM,Rashidkhani B, Saadat N, Shakerhossini R (2019) The effects of synbiotic supplementation on body mass index, metabolic and inflammatory biomarkers, and appetite in patients with metabolic syndrome: a triple-blind randomized controlled trial. J Diet Suppl 16:294–306 Importantly, according to the new definition, the microorganisms in a synbiotic product may not necessarily consume the substrate in that product. The substrate could instead promote the growth of other kinds of good bacteria that already live in the host’s gut. Arena MP, Russo P, Capozzi V, Rascón A, Felis GE, Spano G, Fiocco D (2016) Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect. J Funct Foods 23:12–23

Probiotics and prebiotics are not the same thing. Prebiotics are non-digestible parts of food and nutrients that nourish the good bacteria in your gut. Prebiotics help to encourage growth of that good bacteria. Prebiotics naturally exist in foods and drinks like asparagus, artichokes, garlic, tomatoes, bananas, cow’s milk and more. Mofidi F, Poustchi H, Yari Z, Nourinayyer B, Merat S, Sharafkhah M, Malekzadeh R, Hekmatdoost A (2017) Synbiotic supplementation in lean patients with non-alcoholic fatty liver disease: a pilot, randomised, double-blind, placebo-controlled, clinical trial. Br J Nutr 117:662–668Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995; 125(6):1401-12. doi: 10.1093/jn/125.6.1401. Researchers first proposed combining probiotics and prebiotics into a single product called a “synbiotic” 25 years ago. Probiotics are beneficial bacteria that can help to re-establish the normal microbiota. They are particularly effective when delivered together with a prebiotic, a source of nutrition that stimulates growth. Kim G, Bae J, Kim MJ, Kwon H, Park G, Kim S-J, Choe YH, Kim J, Park S-H, Choe B-H, Shin H, Kang B (2020) Delayed establishment of gut microbiota in infants delivered by cesarean section. Front Microbiol 11:2099. https://doi.org/10.3389/fmicb.2020.02099

Chen T, Kim CY, Kaur A, Lamothe L, Shaikh M, Keshavarzian A, Hamaker BR (2017) Dietary fibre-based SCFA mixtures promote both protection and repair of intestinal epithelial barrier function in a Caco-2 cell model. Food Funct 8:1166–1173 Acid-Resistant Vegan Outer [chlorophyllin] and Inner Capsules [hypromellose, fermented gellan gum, water] Synbiotic D-C has a 2 year shelf life from the date of manufacture. Store in a cool dry place. FAQs Active Fluorescent Units (AFU) testing via flow cytometry for precise enumeration of viable cells in a multi-strain formulation The panel recommends that, ideally, the two components of a synergistic synbiotic would have a “super-additive effect.” In other words, in combination, their effect would be greater than the sum of their individual effects.Enam F, Mansell TJ (2019) Prebiotics: tools to manipulate the gut microbiome and metabolome. J Ind Microbiol Biotechnol 46:1445–1459 Quaresma M, Damasceno S, Monteiro C, Lima F, Mendes T, Lima M, Justino P, Barbosa A, Souza M, Souza E, Soares P (2020) Probiotic mixture containing Lactobacillus spp. and Bifidobacterium spp. attenuates 5-fluorouracil-induced intestinal mucositis in mice. Nutr Cancer 72:1355–1365

Probiotics on the other hand are the friendly bacteria that colonise the gut. They offer benefits for various aspects of health including digestion, immunity, skin health and energy, to name a few. Probiotics are found naturally in fermented foods such as live yoghurt or sauerkraut, but like prebiotics, are also available as food supplements. Read this article to learn more about: What are Probiotics? What does a synbiotic do?

REVIEW article

Bindels LB, Delzenne NM, Cani PD, Walter J (2015) Towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol 12:303–310 Skin, hair and nails can serve as indicators of nutritional deficiencies (e.g. pallid or pale skin, hair thinning or loss, or brittle and weak nails).” Why do we need a healthy skin microbiome? Cordeiro BF, Oliveira ER, da Silva SH, Savassi BM, Acurcio LB, Lemos L, Alves JdL, Carvalho Assis H, Vieira AT, Faria AMC et al (2018) Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice. Front Microbiol 9:2035

Your bio-based tray is made of renewable ingredients—starch, natural fibers, and water—and produced energy-efficiently. It’s fully recyclable and home compostable. H Wilkins, J Sequoia. Probiotics for Gastrointestinal Conditions: A Summary of Evidence. Am Fam Physician. 2017;96(3):170-178. Synbiotics’ health benefits are not limited to your gut health, as they can target areas of your body outside of the gut, such as the skin. Synbiotics are starting to gain traction in the marketplace, but there’s a lot of confusion around the term, even among scientists,” says Kelly Swanson, a professor in the Department of Animal Sciences at the University of Illinois at Urbana-Champaign, Urbana. EFSA (2017) Scientific opinion on the update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA (2017 update). EFSA J 15:1–177

For instance, some bacteria ‘eat’ excess sebum, others clear up dead skin cells, and some produce antifungal and antimicrobial compounds. Madan A, Thompson D, Fowler JC, Ajami NJ, Salas R, Frueh BC, Bradshaw MR, Weinstein BL, Oldham JM, Petrosino JF (2020) The gut microbiota is associated with psychiatric symptom severity and treatment outcome among individuals with serious mental illness. J Affect Disord 264:98–106 Synbiotics as potent functional food: recent updates on therapeutic potential and mechanistic insight Why is strain specificity important? Well, precision is critical, especially with bacteria. Within each species, there are actually multitudes of strains. Just like a french bulldog is quite different from a golden retriever (even though they both belong to the genus and species Canis lupus familiaris), each strain of a bacterial species has its own characteristics and cannot be lumped together synonymously. As an example, Lactobacillus plantarum 299v has been shown to effectively reduce IBS symptoms in a number of trials, whereas administration of Lactobacillus plantarum MF1298 was actually found to worsen them.