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While research is preliminary, modified citrus pectin has the potential to offer benefits for heart disease, cancer, IBS, and even cognition. It may also act as a natural chelating agent, helping individuals to safely detoxify from heavy metals.
L. Calvier, et al., “The Impact of Galectin-3 Inhibition on Aldosterone-Induced Cardiac and Renal Injuries,” JACC Heart Fail. 3(1), 59–67 (2015). One randomized clinical trial with 125 participants who had mild to moderate high LDL (low-density lipoprotein) cholesterol found that use of guar gum plus pectin helped to normalize cholesterol levels. Unmodified citrus pectin does not have the same short, systemically available polysaccharide chains as MCP … and thus remains in the gastrointestinal (GI) tract. And other “modified” pectins may simply indicate that the pectin has been altered in some way, but doesn’t contain the shorter polysaccharide chains and molecular structure required for efficacy.
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In the US, the researched form of MCP is patented for structure-function health claims related to cellular, cardiovascular and immune health, as well as inflammation, fibrosis and toxic metal body burden. Artibani W., Porcaro A.B., De Marco V., Cerruto M.A., Siracusano S. Management of Biochemical Recurrence after Primary Curative Treatment for Prostate Cancer: A Review. Urol. Int. 2017;100:251–262. doi: 10.1159/000481438. J. Jiang, I. Eliaz and D. Sliva, “Synergistic and Additive Effects of Modified Citrus Pectin with Two Polybotanical Compounds in the Suppression of Invasive Behavior of Human Breast and Prostate Cancer Cells,” Integr. Cancer Ther. 12(2), 145–152 (2013). MCP is not alone in the botanical field at inhibiting cancer spread. You might also look at honokiol,which has been extensively studied in preclinical cell and animal models and shown to fight cancer through numerous mechanisms of action. Honokiol is derived from Magnolia officinalis bark, and is highly regarded for its anti-tumour, anti-angiogenic and antioxidant effects. It has also been shown in preclinical studies to enhance the benefits of some chemotherapies and natural agents’. Galectins dampen antitumour immune responses by targeting both lymphoid and myeloid cells 38 (Fig. 2). Notably, galectin–glycan interactions alter the immune landscape in several cancer types 112, 113, 114, 115, 116, 117, 118. Moreover, galectins modulate cancer-associated fibroblasts and can influence their pro-tumorigenic and pro-metastatic activities 119.
Pound C., Partin A., Eisenberger M., Chan D.W., Pearson J.D., Walsh P.C. Natural history of progression after PSA elevation following radical prostatectomy. JAMA. 1999;281:1591–1597. doi: 10.1001/jama.281.17.1591. Mucin-type O-glycosylation is initiated by the actions of polypeptide N-acetylgalactosamine transferases (ppGalNAcTs). Synthesis of core 1 O-glycan structures (Galβ(1–3)GalNAc) is initiated by C1GALT1 (core 1 β(1–3)-galactosyltransferase 1), assisted by the chaperone protein, COSMC. Although both GAL1 and GAL3 can recognize core 1 structures, GAL3 binds with higher affinity. Core 1 can be sialylated by β-galactoside-α(2–3) sialyltransferase 1 (ST3GAL1), elongated or branched. Branching by N-acetylglucosaminyltransferases such as C2GNT1 results in a core 2 O-glycan structure, which can be further elongated by GALTs, generating LacNAc residues. Functional roles of GAL1 have been associated with binding to both core 1 and extended core 2 O-glycans.
The extensive investigations into higher affinity and more selective small-molecule galectin inhibitors has led to an improved understanding of the crucial interactions that underlie their inhibitory activity and enhanced selectivity 179. The use of GB0139 ( 11) for IPF and GB1211 for NASH laid the foundatio Lactose (Lac) and LacNAc disaccharides, the natural galectin ligands in glycoconjugates, have been evaluated as galectin inhibitors 37, 184. Substitution of LacNAc at O3′ with aromatic moieties has been explored extensively as a means to generate new and favourable π–arene interactions with the conserved Arg144 residue; this effort has resulted in the development of several effective GAL3 ligands, including a LacNAc derivative 163, 185, 186 ( 6, Fig. 3d). Alternatively, synthetic lactulose amines evaluated as galectin modulators were found to induce tumour cell apoptosis and inhibit homotypic cell aggregation and EC morphogenesis 187. More recently, Kishor and colleagues 188 explored interactions of GAL1 and GAL3 with lactulose ( 7, Fig. 3e) by crystallography and proposed this disaccharide as another scaffold for the design of novel galectin inhibitors. Take one 5 gram scoop 3 times daily with liquid on any empty stomach or as recommended by your healthcare practitioner. This product is designed to be taken on an empty stomach, at least 30 minutes before or 2 hours after food, or 2 hours either before or after other supplements or medications.
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